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The aim is to examine the history and significance of pethidine as an opioid analgesic and its influence on pain management.

On pethidine: The ‘accidental’ opioid that became a ‘model’ analgesic agent

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The aim is to examine the history and significance of pethidine as an opioid analgesic and its influence on pain management.
Analysed historical publications on pethidine's discovery and use as a synthetic opioid.
Reviewed pharmacokinetic studies involving pethidine in healthy volunteers and patients.
Explored the development of patient-controlled analgesia techniques and neuraxial administration of pethidine.
Pethidine was found to have weaker analgesic properties compared to morphine but was effectively marketed for pain relief.
Initial intravenous infusions based on pharmacokinetic data improved postoperative pain management but did not eliminate variability in pain response.
The understanding of spinal opioid receptors facilitated the integration of pethidine into clinical practice for severe pain relief.

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This historical analysis explores pethidine's development as an opioid analgesic, highlighting its impact on pain management techniques.

Mather et al. (2026) studied this question.

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