Cu-Catalyzed Interrupted [3 + 2] Cycloaddition of Trifluoroacetonitrile Imines with Terminal Alkynes: Facile Access to Diverse Tetrasubstituted 3-Trifluoromethyl Pyrazoles

Xiaowen Yu; Weiguang Kong; Feifei Fan; Yanfan Huang; Shukui Shi; Huanping Xie; Heyun Sheng; Ting Li

doi:10.1039/d6cc02668k

January 1, 2026Chemical Communications

Cu-Catalyzed Interrupted [3 + 2] Cycloaddition of Trifluoroacetonitrile Imines with Terminal Alkynes: Facile Access to Diverse Tetrasubstituted 3-Trifluoromethyl Pyrazoles

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Key Points

To develop an efficient synthetic route for producing diverse tetrasubstituted 3-trifluoromethyl pyrazoles using cu-catalyzed cycloaddition.
Utilized cu-catalyzed interrupted [3 + 2] cycloaddition
Employed trifluoroacetonitrile imines and terminal alkynes
Assessed the efficiency of the synthesis in generating fully substituted variants.
Successfully synthesized a range of tetrasubstituted 3-trifluoromethyl pyrazoles.
Demonstrated improved access to complex pyrazole structures with high yield and selectivity.
Highlighted the advantages over traditional synthetic methods.

Implication

Reveals efficient synthesis of diverse tetrasubstituted 3-trifluoromethyl pyrazoles, suggesting a novel approach to pyrazole construction.

Abstract

Trifluoromethylated pyrazoles represent high-value heterocyclic scaffolds widely utilized in pharmaceutical and agrochemical sectors, while conventional synthetic strategies suffer from severe limitations in efficient access to their fully substituted variants. Herein,...

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Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a323bbcd50b63ecad206322 https://doi.org/10.1039/d6cc02668k

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Cu-Catalyzed Interrupted [3 + 2] Cycloaddition of Trifluoroacetonitrile Imines with Terminal Alkynes: Facile Access to Diverse Tetrasubstituted 3-Trifluoromethyl Pyrazoles

Key Points

Implication

Abstract

Discussion

Cite This Study

Cu-Catalyzed Interrupted [3 + 2] Cycloaddition of Trifluoroacetonitrile Imines with Terminal Alkynes: Facile Access to Diverse Tetrasubstituted 3-Trifluoromethyl Pyrazoles

Key Points

Implication

Abstract

Discussion

Cite This Study

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