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June 17, 2026European Journal of Nuclear Medicine and Molecular ImagingOpen Access

Diagnostic performance of 18F-FDG PET/CT in the prediction of axillary lymph node metastasis in Luminal A breast cancer

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Authors

KSKerim SekerHGHüsnü Çağrı GençTKTülay Koç

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Overview

Randomized trial assesses axillary lymph node metastasis prediction in Luminal A breast cancer using 18F-FDG PET/CT, indicating significant improvements with combined models.

Key Points

  • This study aims to evaluate the diagnostic performance of 18F-FDG PET/CT for predicting axillary lymph node metastasis in patients with Luminal A breast cancer.
  • Retrospective evaluation of 279 treatment-naive female patients diagnosed with Luminal A breast cancer.
  • Assessment of both visual analysis and multiple quantitative parameters of PET/CT including SUVmax and TLG.
  • Analysis of diagnostic performance via ROC, NRI, IDI, and DCA.
  • ALN metastasis confirmed in 152 (54.5%) patients with significant differences in quantitative parameters (p < 0.001).
  • Axillary SUVmax achieved an AUC of 0.881, outperformed visual assessment (AUC: 0.851, p = 0.031).
  • The combined model improved diagnostic power with an AUC of 0.889, showing a 29% correct reclassification of false negatives and a 41.4% improvement in overall discrimination.

Cite This Study

Seker et al. (2026) studied this question.

synapsesocial.com/papers/6a323bf5d50b63ecad2064f6https://doi.org/10.1007/s00259-026-07986-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic performance of preoperative 18F-FDG PET/CT in detecting axillary lymph node metastasis in breast cancer2026
  2. 2Sensitivity, Specificity, and Accuracy of Ultrasound, Mammography, and 18F-FDG PET/CT in Diagnosing Breast Cancer Metastasis to Axillary Lymph Nodes: A Single-Center Experience2026 · 1 citations
  3. 3Prediction of the axillary lymph-node metastatic burden of breast cancer by 18F-FDG PET/CT-based radiomics2024 · 4 citations
  4. 4Diagnostic value of [18F]AlF-NOTA-FAPI-04 PET/CT in breast cancer: comparison with conventional imaging2026
  5. 5Evaluating the accuracy of 18F-FDG PET-MRI scan in detecting regional lymph node disease in high risk breast cancer patients: PETAL study2024