Economically Feasible Multicomponent Construction of Diverse 2-Amino-alkoxypyridine-3,5-dicarbonitriles Using [BMIM]OH as a Catalyst and Their Docking Studies

A successful one-pot, multicomponent, and eco-efficient technique has been developed for the construction of 2-amino-alkoxypyridine-3,5-dicarbonitriles. This reaction entails a tandem pseudo-three-component process employing arylaldehyde, dicyanomethane, and alcohol (methanol, ethanol, or propanol), catalyzed by [bmim]OH at 80°C. This synthetic approach is characterized by its consistently high yields (85–92%), as well as its simple, more efficient, low-cost, column-free chromatography, solvent-free, and lesser reaction periods (120–160 min). The method not only streamlines the production process but also enhances the diversity of accessible derivatives and their subsequent applications in medicinal chemistry. 3BL6 protein of bacteria is screened for drug-likeness properties for synthesized compounds.