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This study aims to evaluate how different designs of return cannulas affect oxygen delivery and recirculation in VV-ECMO.

Digital performance testing reveals how redesigned return cannulas can enhance VV-ECMO performance

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This study aims to evaluate how different designs of return cannulas affect oxygen delivery and recirculation in VV-ECMO.
Computational modeling analyzed six different return cannula designs
Three ECMO flow rates (2, 4, and 6 L/min) were tested
Evaluated outcomes included oxygen delivery, recirculation, thrombosis, and hemolysis
At 2 L/min, all cannulas exhibited 78% oxygen saturation and 1.6% recirculation.
At 6 L/min, closed-tip cannulas reduced recirculation by 40-50% and increased oxygen saturation by 6%.
The partial pressure of oxygen increased by up to 151% compared to standard cannula used in practice.

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Randomized trial examines redesigned return cannulas to improve oxygen delivery in VV-ECMO, suggesting enhanced performance.

Ondrušová et al. (2026) studied this question.

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