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This study aims to assess the acute and sub-acute toxic effects of ethyl acetate fraction from Vernonia amygdalina in laboratory rodents.

June 17, 2026Open Access

Biochemical and Haematological Effects of Acute and Sub-acute Administration of Ethyl Acetate Fraction of Vernonia amygdalina Leaf in Laboratory Rodents

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Randomized trial evaluates toxicological effects of Vernonia amygdalina in rodents, indicating no significant harm at tested doses.

This study aims to assess the acute and sub-acute toxic effects of ethyl acetate fraction from Vernonia amygdalina in laboratory rodents.
Conducted acute and sub-acute assessments following OECD guidelines 423 and 407.
Acute phase involved administering 2000 mg/kg dosage to male and female mice; sub-acute phase involved female rats receiving 100, 200, and 400 mg/kg over 28 days.
Evaluated mortality, behavior changes, weight variations, and biochemical and haematological parameters.
No observable behavioral changes or mortality in both acute and sub-acute studies.
No statistically significant differences in weight or biochemical/haematological indices noted.
Mild histological changes observed at the highest dose of 400 mg/kg, but overall, findings suggest a large safety margin.

Aitokhuehi et al. (2026) studied this question.

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