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This research aims to evaluate the effectiveness of ecofriendly antibacterial nanoparticles in promoting healing in diabetic skin infection models.

June 17, 2026Scientific ReportsOpen Access

Biosynthesis of ecofriendly antibacterial nanoparticles with healing effects in a murine diabetic skin infection model

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Randomized trial reveals enhanced healing of diabetic skin infections in a murine model using ecofriendly nanoparticles.

This research aims to evaluate the effectiveness of ecofriendly antibacterial nanoparticles in promoting healing in diabetic skin infection models.
Synthesis of silver, zinc oxide, and chitosan-tripolyphosphate nanoparticles using green tea extract and gamma irradiation.
Assessment of antibacterial properties against various multidrug-resistant bacterial strains.
In vivo evaluation of healing effects in a CD1 mouse model of diabetic skin infection.
AgNPs achieved significant bacterial kill rates with > 10 log10 CFU/mL reduction within 2–6 hours.
In vivo treatment resulted in a 4 Log10 unit reduction in bacterial load and decreased NF-kB inflammatory marker levels.
Histopathology showed complete epidermal regeneration and increased fibroblast proliferation in treated tissues compared to controls.

Mustafa et al. (2026) studied this question.

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