Human Neurobiology as an Active Granular-Poroelastic Neuroarchitecture Within Coupled Gravito-Thermo-Electro-Poroelastic Framework

Human neurobiology is conventionally interpreted through molecular signalling, electrophysiology, neurotransmission, and systems neuroscience. However, neural systems simultaneously function as mechanically constrained, fluid-coupled, thermodynamically active biological architectures embedded within hydrostatic, metabolic, and electrochemical environments. The present article advances a conceptual framework in which human neurobiology is interpreted as a gravito–thermo–electro–poroelastic system integrating structural mass organization, metabolic heat generation, cerebrospinal fluid dynamics, vascular pulsatility, tissue mechanics, ionic gradients, and recurrent electrochemical signalling. Within this framework, intrinsic gravitation is conservatively interpreted as a structural background associated with hydrostatic equilibrium, cranial–spinal organization, buoyancy-mediated stabilization, tissue loading, and pressure redistribution rather than as an isolated dominant neuronal force.