Key result
Coronary spasm and vasomotor dysfunction may underlie ~50% of MINOCA and chronic chest pain cases.
Why the study?
Coronary spasm and vasomotor dysfunction may underlie more than half of MINOCA cases and represent an important cause of chronic outpatient chest pain.
Coronary spasm and vasomotor dysfunction are increasingly recognized as the underlying cause in over half of MINOCA cases.
Prompts spasm provocation testing in MINOCA; extends RCT evidence linking vasomotor dysfunction to most cases.
Increasing evidence has shown that coronary spasm and vasomotor dysfunction may be the underlying cause in more than half of myocardial infarctions with non-obstructive coronary arteries (MINOCA) as well as an important cause of chronic chest pain in the outpatient setting. We review the contemporary understanding of coronary spasm and related vasomotor dysfunction of the coronary arteries, the pathophysiology and prognosis, and current and emerging approaches to diagnosis and evidence-based treatment.
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Yaker et al. (2024) conducted a review in Myocardial infarctions with non-obstructive coronary arteries (MINOCA) and chronic chest pain. Coronary spasm and vasomotor dysfunction was evaluated. Coronary spasm and vasomotor dysfunction may be the underlying cause in more than half of myocardial infarctions with non-obstructive coronary arteries (MINOCA) and chronic chest pain.
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