Key result
The highest tertile of the Triglyceride glucose index was independently associated with a significantly increased risk of coronary artery stenosis (OR 3.19) compared to the lowest tertile in asymptomatic subjects with type 2 diabetes.
Why the study?
Is a higher TyG index associated with an increased risk of coronary artery stenosis in asymptomatic subjects with type 2 diabetes?
Population
888 asymptomatic adults with type 2 diabetes but without previous history of coronary heart disease. Mean…
Comparison
Higher tertiles of Triglyceride glucose index… vs Lowest tertile of TyG index
Design
Cross-sectional
Authors
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Should not yet change CAS risk assessment in T2D; leaves open whether TyG index improves stratification beyond standard factors.
Observational (n=888)
Is a higher TyG index associated with an increased risk of coronary artery stenosis in asymptomatic subjects with type 2 diabetes?
Odds Ratio: 3.19 (95% CI 1.371–7.424)
Absolute Event Rate: 14% vs 7.8%
p-value: p=0.007
The TyG index is a simple, inexpensive marker of insulin resistance that independently associates with significant coronary artery stenosis in asymptomatic patients with type 2 diabetes.
Lee et al. (2016) conducted an observational in Type 2 diabetes (n=888). High Triglyceride glucose (TyG) index (highest tertile) vs. Low Triglyceride glucose (TyG) index (lowest tertile) was evaluated on Significant coronary artery stenosis (≥70% stenosis) (OR 3.19, 95% CI 1.371-7.424, p=0.007). The highest tertile of the Triglyceride glucose index was independently associated with a significantly increased risk of coronary artery stenosis (OR 3.19) compared to the lowest tertile in asymptomatic subjects with type 2 diabetes.
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