Key result
Exercise-based cardiac rehabilitation did not significantly reduce all-cause mortality (HR 0.83; 95% CI 0.67-1.04) or all-cause hospitalization (HR 0.90; 95% CI 0.76-1.06) in patients with HFrEF.
Why the study?
Does exercise-based cardiac rehabilitation reduce mortality and hospitalisation in patients with heart failure with reduced ejection fraction?
Meta-Analysis (n=3,912)
Randomized
Yes
Does exercise-based cardiac rehabilitation reduce mortality and hospitalisation in patients with heart failure with reduced ejection fraction?
Hazard Ratio: 0.83 (95% CI 0.67–1.04)
Exercise-based cardiac rehabilitation did not significantly reduce mortality or hospitalization in patients with HFrEF, though wide confidence intervals suggest uncertainty.
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Does not support reduced mortality or hospitalization with exercise-based cardiac rehabilitation in HFrEF; leaves open benefit given wide CIs.
Taylor et al. (2018) conducted a meta-analysis in Heart failure with reduced ejection fraction (n=3,912). Exercise-based cardiac rehabilitation vs. no exercise control was evaluated on all-cause mortality (HR 0.83, 95% CI 0.67-1.04). Exercise-based cardiac rehabilitation did not significantly reduce all-cause mortality (HR 0.83; 95% CI 0.67-1.04) or all-cause hospitalization (HR 0.90; 95% CI 0.76-1.06) in patients with HFrEF.
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