Key result
Low postoperative CRP rules out anastomotic leak with ~99% negative predictive value.
Why the study?
Anastomotic leak remains a serious complication after restorative colorectal surgery, and most published studies on inflammatory markers to predict it are based on heterogeneous retrospectively collected data.
Does serum CRP measurement predict anastomotic leak in patients undergoing elective colorectal surgery?
Observational (n=361)
Open-label
No
Does serum CRP measurement predict anastomotic leak in patients undergoing elective colorectal surgery?
CRP levels < 182 mg/L on postoperative day 3 are a strong negative predictor for anastomotic leak following elective colorectal surgery, potentially allowing for early discharge.
Answers are grounded in this paper and cite their sources.
May aid AL prediction after colorectal surgery; leaves open routine use pending prospective validation.
Anastomotic leak (AL) remains a serious complication following restorative colorectal surgery. There are published studies on the use of c reactive protein (CRP), procalcitonin, and white cell count (WCC) to predict AL. 1 However, most are based on heterogeneous retrospectively collected data.
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Choi et al. (2023) conducted an observational in Elective colorectal surgery with primary anastomosis (n=361). C-reactive protein (CRP) level vs. No anastomotic leak was evaluated on Median CRP level at postoperative day 3 (mg/L) (p=< 0.00001). A C-reactive protein level < /L on postoperative day 3 strongly predicted the absence of anastomotic leak, with 88% sensitivity, 87% specificity, and a 99.1% negative predictive value.
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