Key result
Nitroxyl (HNO) increases the maximal activation of SERCA in adult rat ventricular myocytes via S-glutathiolation at cysteine 674.
Population
adult rat ventricular myocytes
Design
Preclinical
Authors
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No immediate clinical implications; leaves open translation of rat myocyte SERCA effects to human therapy.
Nitroxyl exerts its inotropic and lusitropic effects in the myocardium by activating SERCA through S-glutathiolation at cysteine 674.
Lancel et al. (2009) studied this question. Nitroxyl (HNO) derived from Angeli's salt was evaluated on Maximal rate of thapsigargin-sensitive Ca2+ uptake mediated by SERCA and S-glutathiolation of SERCA. Nitroxyl (HNO) increases the maximal activation of SERCA in adult rat ventricular myocytes via S-glutathiolation at cysteine 674.
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