Key result
Body fat accumulation is associated with concentric left ventricular geometry and increased myocardial mass, relationships that appear to be mediated in part by blood pressure and insulin levels.
Population
103 subjects including 60 patients with obesity (BMI 31-52) and 43 non-obese subjects (BMI 18-27)
Design
Cross-sectional
Authors
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Body fat links to concentric LV remodeling partly via BP and insulin; hypothesis-generating and requires longitudinal confirmation before guiding care.
Cross-Sectional (n=103)
The concentric left ventricular geometry associated with body fat accumulation appears to be mediated, at least in part, by blood pressure and insulin levels.
Kristjan Karason (2003) conducted a cross-sectional in Obesity (n=103). Body fat accumulation vs. Non-obese subjects (BMI 18-27) was evaluated on Left ventricular mass and geometry (relative wall thickness). Body fat accumulation is associated with concentric left ventricular geometry and increased myocardial mass, relationships that appear to be mediated in part by blood pressure and insulin levels.
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