Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 25, 2013Journal of EndocrinologyOpen Access

High-salt diets during pregnancy affected fetal and offspring renal renin–angiotensin system

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does a maternal high-salt diet during pregnancy affect the fetal and offspring renal renin-angiotensin system in sheep?

Population

Ovine fetuses and offspring (aged 15 and 90 days) from 33 pregnant ewes

Comparison

High-salt diet fed to pregnant ewes for 60 days… vs Normal-salt diet fed to pregnant ewes for 60…

Design

Preclinical, Hormone assays and data analysis were handled in a blind manner

Follow-up

Up to 90 days postnatal

Authors

CMCaiping MaoSoochow UniversityRLRong LiuJishou UniversityLBLe BoXuzhou Medical College

Discussion

Loading...

Member takes

Overview

Maternal high-salt intake may program offspring renal risk via RAS in sheep; leaves open human relevance and interventions.

Structured PICO

Does a maternal high-salt diet during pregnancy affect the fetal and offspring renal renin-angiotensin system in sheep?

P
Population
Ovine fetuses and offspring (aged 15 and 90 days) from 33 pregnant ewes
I
Intervention
High-salt diet (8% NaCl) fed to pregnant ewes for 60 days during gestational days 70-130
C
Comparator
Normal-salt diet (0.6% NaCl) fed to pregnant ewes for 60 days during gestational days 70-130
O
Outcome
Fetal renal functions, plasma hormones, and mRNA and protein expressions of key elements of the renal renin-angiotensin systemsurrogate

High maternal salt intake during pregnancy alters fetal renal development and the local renal renin-angiotensin system, with effects persisting into postnatal life.

Limitations

  • Food intake was not measured

Cite This Study

Mao et al. (2013) studied this question.

synapsesocial.com/papers/6a3300fbc832e26dfd08bf0ehttps://doi.org/10.1530/joe-13-0139
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An unexpected role for angiotensin II in the link between dietary salt and proximal reabsorption2006 · 78 citations
  2. 2Evolving Concepts of the Intrarenal Renin-Angiotensin System in Health and Disease: Contributions of Molecular Biology1991 · 31 citations
  3. 3Angiotensinogen Expression Is Enhanced in the Progression of Glomerular Disease2011 · 22 citations
  4. 4Sodium and blood pressure2002 · 70 citations
  5. 5Dietary Sodium Intake and Its Relation to Human Health: A Summary of the Evidence2006 · 22 citations