Key result
Current use of beta-blockers alone (OR 0.77; 95% CI 0.72-0.83) or combined with thiazides (OR 0.71; 95% CI 0.64-0.79) was associated with a reduced risk of fractures compared with nonuse.
Why the study?
Does the use of beta-blockers alone or in combination with thiazides reduce the risk of fractures in adults?
Population
151,420 adults aged 30 to 79 years, comprising 30,601 cases with an incident fracture diagnosis between 1993…
Comparison
Current use of beta-blockers only or combined… vs Patients who did not use either beta-blockers or…
Design
Case-control
Authors
Loading...
May indicate fracture protection with beta-blockers; extends observations but remains hypothesis-generating and should not yet change practice.
Case-Control (n=151,420)
Yes
Does the use of beta-blockers alone or in combination with thiazides reduce the risk of fractures in adults?
Odds Ratio: 0.77 (95% CI 0.72–0.83)
Current use of beta-blockers, alone or in combination with thiazide diuretics, is associated with a significantly reduced risk of fractures.
Raymond G. Schlienger (2004) conducted a case-control in Fractures (n=151,420). Beta-blockers vs. No use of beta-blockers or thiazide diuretics was evaluated on Incident fracture (OR 0.77, 95% CI 0.72-0.83). Current use of beta-blockers alone (OR 0.77; 95% CI 0.72-0.83) or combined with thiazides (OR 0.71; 95% CI 0.64-0.79) was associated with a reduced risk of fractures compared with nonuse.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: