Key result
Hypoalbuminemia in patients with acute heart failure was associated with an almost four-fold increased risk of in-hospital mortality (OR 3.77) compared to normal albumin levels.
Why the study?
Hypoalbuminemia is common in HF, but its pathophysiology and clinical implications are poorly understood, with no consensus on its prognostic value.
Does hypoalbuminemia predict increased mortality and rehospitalization in patients with heart failure?
Population
44,048 patients with HF across 48 studies
Comparison
Hypoalbuminemia vs normal albumin levels
Design
Systematic review and meta-analysis
Authors
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HA signals higher in-hospital mortality risk in acute HF; leaves open whether correction improves outcomes.
Meta-Analysis (n=44,048)
Does hypoalbuminemia predict increased mortality and rehospitalization in patients with heart failure?
Odds Ratio: 3.77 (95% CI 1.96–7.23)
p-value: p=<0.001
Hypoalbuminemia is a widely available and affordable biomarker that strongly predicts in-hospital and long-term mortality in patients with heart failure, with predictive accuracy comparable to BNP.
Iskandarani et al. (2021) conducted a meta-analysis in Heart failure (n=44,048). Hypoalbuminemia vs. Normal serum albumin was evaluated on In-hospital mortality in acute heart failure (OR 3.77, 95% CI 1.96-7.23, p=<0.001). Hypoalbuminemia in patients with acute heart failure was associated with an almost four-fold increased risk of in-hospital mortality (OR 3.77) compared to normal albumin levels.
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