Why the study?
Heart failure is the end-stage of various diseases, especially ICM and DCM, but their common molecular mechanisms required investigation.
Population
ICM, DCM, and control samples from six public datasets and a tissue microarray
Comparison
ICM or DCM samples vs control
Design
Bioinformatic gene expression analysis with tissue microarray and western blot validation
Authors
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ASPN upregulation in ICM/DCM hearts is hypothesis-generating; leaves open biomarker or therapeutic relevance pending prospective validation.
Key points are not available for this paper at this time.
Zhang et al. (2021) studied this question.