Key result
The Mechanisms of Diuretic Resistance Study is designed to establish a prospective cohort to investigate diuretic resistance mechanisms and biomarkers in acute decompensated heart failure.
Why the study?
Mechanisms of diuretic resistance in ADHF are largely extrapolated from other populations, and currently available tools cannot rapidly or reliably diagnose it.
What are the mechanisms of diuretic resistance and can urine biomarkers predict it in patients hospitalized with acute decompensated heart failure?
What are the mechanisms of diuretic resistance and can urine biomarkers predict it in patients hospitalized with acute decompensated heart failure?
The Mechanisms of Diuretic Resistance (MDR) Study is designed to investigate the mechanisms of diuretic resistance and identify predictive urine biomarkers in patients with acute decompensated heart failure.
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May guide future diuretic strategies in acute HF; leaves open clinical validation of resistance biomarkers.
Cox et al. (2020) studied Acute decompensated heart failure (ADHF). Loop diuretic administration was evaluated on Mechanisms of diuretic resistance and urine biomarkers to predict loop diuretic resistance. The Mechanisms of Diuretic Resistance Study is designed to establish a prospective cohort to investigate diuretic resistance mechanisms and biomarkers in acute decompensated heart failure.
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