Key result
Transcatheter aortic valve replacement significantly improved diastolic cardiac function, as evidenced by a decrease in left ventricular ejection time from 303.99 ms to 264.01 ms at one week post-operation.
Why the study?
Hemodynamic changes in patients with aortic stenosis undergoing TAVR had not been completely investigated.
Does transcatheter aortic valve replacement (TAVR) improve hemodynamic parameters measured by impedance cardiography in patients with severe aortic stenosis?
Population
74 patients with AS undergoing TAVR
Comparison
Preserved LVEF (≥50%, n=47) vs reduced LVEF (<50%, n=27)
Design
Observational cohort study
Follow-up
1 week
Authors
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TAVR-linked LV ejection time reduction should not yet change practice; leaves open whether diastolic gains affect clinical outcomes in aortic stenosis.
Observational (n=74)
No
Does transcatheter aortic valve replacement (TAVR) improve hemodynamic parameters measured by impedance cardiography in patients with severe aortic stenosis?
Absolute Event Rate: 264.01% vs 303.99%
p-value: p=<0.001
Impedance cardiography demonstrates that TAVR provides immediate improvement in diastolic function and preload, though systolic function and afterload may not immediately improve in patients with reduced LVEF.
Wan et al. (2022) conducted an observational in Severe aortic stenosis (n=74). Transcatheter aortic valve replacement (TAVR) vs. Baseline (pre-operation) was evaluated on Left ventricular ejection time (LVET) (p=<0.001). Transcatheter aortic valve replacement significantly improved diastolic cardiac function, as evidenced by a decrease in left ventricular ejection time from 303.99 ms to 264.01 ms at one week post-operation.
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