Key result
In patients with severe aortic stenosis, overweight and obesity were associated with greater intraendomyocardial fibrosis and lipid infiltration, and an increased risk of subclinical systolic dysfunction (OR 1.2 per BMI unit).
Why the study?
Does overweight and obesity increase intraendomyocardial fibrosis and lipid infiltration, and worsen global longitudinal strain in patients with severe aortic stenosis?
Cross-Sectional (n=44)
Blinded assessors
No
Does overweight and obesity increase intraendomyocardial fibrosis and lipid infiltration, and worsen global longitudinal strain in patients with severe aortic stenosis?
Odds Ratio: 1.2 (95% CI 1.03–1.42)
p-value: p=0.019
In patients with severe aortic stenosis, overweight and obesity are associated with greater intraendomyocardial fibrosis and lipid infiltration, which correlates with worse global longitudinal strain.
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Associates obesity with myocardial fibrosis in severe aortic stenosis; leaves open causal effects and intervention benefits.
Ávila‐Vanzzini et al. (2016) conducted a cross-sectional in Severe aortic stenosis (n=44). Overweight and obesity (BMI ≥ 25 kg/m2) vs. Non-obese (BMI < 25 kg/m2) was evaluated on Significant subclinical systolic dysfunction (GLS < -14%) per unit increase in BMI (OR 1.2, 95% CI 1.03-1.42, p=0.019). In patients with severe aortic stenosis, overweight and obesity were associated with greater intraendomyocardial fibrosis and lipid infiltration, and an increased risk of subclinical systolic dysfunction (OR 1.2 per BMI unit).
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