Key result
Metabolic syndrome in patients with aortic stenosis was associated with lower ejection fraction and increased intramyocyte lipid accumulation, correlating with higher SREBP-1c and PPARγ levels (P<0.001).
Why the study?
Does metabolic syndrome increase myocardial lipid accumulation and SREBP-1c/PPARγ expression in patients with aortic stenosis?
Population
117 patients undergoing surgical aortic valve replacement for isolated aortic stenosis, including 56 with…
Comparison
Presence of metabolic syndrome vs Absence of metabolic syndrome
Design
Cross-sectional
Authors
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May inform lipotoxicity risk stratification in MS with AS; extends mechanistic insights into pressure-overload cardiomyopathy.
Observational (n=117)
Does metabolic syndrome increase myocardial lipid accumulation and SREBP-1c/PPARγ expression in patients with aortic stenosis?
p-value: p=<0.001
Metabolic syndrome is associated with increased myocardial lipid accumulation and upregulation of the SREBP-1c/PPARγ pathway, which may contribute to heart dysfunction in patients with aortic stenosis.
Marfella et al. (2009) conducted an observational in Metabolic syndrome and aortic stenosis (n=117). Metabolic syndrome vs. No metabolic syndrome was evaluated on Ejection fraction and intramyocyte lipid accumulation (p=<0.001). Metabolic syndrome in patients with aortic stenosis was associated with lower ejection fraction and increased intramyocyte lipid accumulation, correlating with higher SREBP-1c and PPARγ levels (P<0.001).
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