Key result
Global work index better discriminates preserved LVEF ATTR from HCM than GLS with ~89% sensitivity.
Why the study?
Impaired myocardial work indexes occur in both ATTR and nonobstructive HCM, but comparative studies between these conditions were lacking.
Does myocardial work analysis differentiate between transthyretin cardiac amyloidosis, hypertrophic cardiomyopathy, and hypertension?
Observational (n=83)
Yes
Does myocardial work analysis differentiate between transthyretin cardiac amyloidosis, hypertrophic cardiomyopathy, and hypertension?
Effect estimate: 89% sensitivity, 55% specificity
p-value: p=0.013
Myocardial work indexes, specifically GWI and GCW, are more impaired in ATTR compared to HCM and HTN, and GWI offers better discriminative value than GLS alone in patients with preserved LVEF.
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May aid ATTR vs HCM differentiation in preserved LVEF; leaves open prospective validation before clinical adoption.
Gregorio et al. (2023) conducted an observational in Transthyretin cardiac amyloidosis and nonobstructive hypertrophic cardiomyopathy (n=83). Myocardial work analysis (Global Work Index) vs. Global longitudinal strain (GLS) was evaluated on Discrimination of ATTR with preserved LVEF from HCM (89% sensitivity, 55% specificity, p=0.013). Global work index ≤1,419 mm Hg% was a better discriminator of preserved LVEF transthyretin cardiac amyloidosis from hypertrophic cardiomyopathy than global longitudinal strain (P=0.013).
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