Key result
Female sex did not influence the acute impairments in popliteal artery flow-mediated dilation (-2.6% vs -2.8% in men; P>0.76) following a 3-hour bout of prolonged sitting.
Why the study?
It was uncertain whether popliteal endothelial-dependent vasoconstrictor responses are affected by prolonged sitting and whether sex differences exist.
Does sex influence the impairments in popliteal endothelial-dependent vasodilator or vasoconstrictor responses following prolonged sitting in young adults?
Population
10 men and 10 women with similar habitual physical activity and sedentary time
Comparison
Popliteal FMD and L-FMC before vs after a 3-h bout of prolonged sitting, compared by sex
Follow-up
3-h
Authors
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No sex differences seen in sitting-induced endothelial impairment among young adults; leaves open generalizability to older or higher-risk groups.
Observational (n=20)
Does sex influence the impairments in popliteal endothelial-dependent vasodilator or vasoconstrictor responses following prolonged sitting in young adults?
Absolute Event Rate: -2.6% vs -2.8%
p-value: p=>0.76
Acute impairments in conduit artery endothelial health associated with uninterrupted sitting are not influenced by sex in young, healthy adults.
O’Brien et al. (2019) conducted an observational in Healthy (n=20). Female sex vs. Male sex was evaluated on Prolonged sitting-induced impairments in popliteal flow-mediated dilation (FMD) (p=>0.76). Female sex did not influence the acute impairments in popliteal artery flow-mediated dilation (-2.6% vs -2.8% in men; P>0.76) following a 3-hour bout of prolonged sitting.
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