Key result
Flow-mediated vasodilation displayed diurnal variation in healthy women, peaking at 2:00 AM (5.1 ± 0.9%) compared to a nadir at 2:00 PM (3.1 ± 0.4%).
Why the study?
Does flow-mediated vasodilation exhibit diurnal variation in healthy premenopausal women?
Population
16 healthy, nonsmoking premenopausal women
Design
Cohort
Follow-up
24 hours
Authors
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May require time-of-day standardization for FMD testing in women; leaves open whether variation affects cardiovascular risk or interventions.
Observational (n=16)
Does flow-mediated vasodilation exhibit diurnal variation in healthy premenopausal women?
Endothelium-dependent and -independent vasodilation in the brachial artery of healthy women display diurnal variation, with flow-mediated vasodilation peaking at 2:00 AM.
Ringqvist et al. (2000) conducted an observational in Healthy (n=16). Time of day (diurnal variation) was evaluated on Flow-mediated vasodilation (FMD%). Flow-mediated vasodilation displayed diurnal variation in healthy women, peaking at 2:00 AM (5.1 ± 0.9%) compared to a nadir at 2:00 PM (3.1 ± 0.4%).
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