Key result
Type 1 diabetes significantly increased coronary artery calcification prevalence in women compared to controls (47% vs 21%; OR 3.6, P<0.001), eliminating the typical sex difference.
Why the study?
Are lipid transfer protein activities associated with coronary artery calcification in type 1 diabetic patients compared to nondiabetic controls?
Cross-Sectional (n=389)
Are lipid transfer protein activities associated with coronary artery calcification in type 1 diabetic patients compared to nondiabetic controls?
Odds Ratio: 3.6
Absolute Event Rate: 47% vs 21%
p-value: p=<0.001
Higher cholesteryl ester transfer is a risk factor for coronary artery calcification, but does not explain the loss of female cardioprotection against CAC in type 1 diabetes.
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Eliminates typical female CAC protection in type 1 diabetes; leaves open lipid transfer protein mediation and needs prospective confirmation.
Colhoun et al. (2001) conducted a cross-sectional in Type 1 diabetes and coronary artery calcification (n=389). Type 1 diabetes vs. Nondiabetic control subjects was evaluated on Prevalence of coronary artery calcification (CAC) in women (OR 3.6, p=<0.001). Type 1 diabetes significantly increased coronary artery calcification prevalence in women compared to controls (47% vs 21%; OR 3.6, P<0.001), eliminating the typical sex difference.
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