Key result
Alpha-thrombin induced hypertrophy and enhanced atrial natriuretic factor expression in primary neonatal rat ventricular myocytes via protein kinase C and tyrosine kinase pathways.
Population
Primary neonatal rat ventricular myocytes
Comparison
Alpha-thrombin and alpha Th-R agonist peptide… vs Non-agonist peptide FLLRNPND and specific…
Design
Preclinical
Follow-up
48 h
Authors
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May promote myocyte hypertrophy via PKC/tyrosine kinase in vitro; extends mechanistic insights but leaves open in vivo human relevance.
Extracellular proteases like alpha-thrombin can act as regulators of myocardial cell gene expression and growth, inducing hypertrophy and ANF expression.
Glembotski et al. (1993) studied Myocardial cell hypertrophy. Alpha-thrombin was evaluated on Hypertrophy, sarcomeric organization, and enhanced atrial natriuretic factor (ANF) expression. Alpha-thrombin induced hypertrophy and enhanced atrial natriuretic factor expression in primary neonatal rat ventricular myocytes via protein kinase C and tyrosine kinase pathways.
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