Key result
Alpha 1-adrenergic stimulation and phorbol ester shifted the intracellular pH dependence of Na-H exchange by 0.10-0.15 pH units in the alkaline direction in adult rat heart myocytes.
Population
Adult rat heart myocytes
Design
Preclinical
Authors
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May support PKC-mediated Na-H exchange regulation in myocytes; leaves open human translation and therapeutic targeting.
Effect estimate: 0.10-0.15 pH units shift
Adrenergic stimulation of cardiac Na-H exchange is mediated by an alpha 1-adrenergic mechanism that likely involves the activation of protein kinase C.
Wallert et al. (1992) studied this question. Phorbol ester and alpha 1-adrenergic agonist (6-fluoronorepinephrine) was evaluated on Intracellular pH dependence of Na-H exchange (0.10-0.15 pH units shift). Alpha 1-adrenergic stimulation and phorbol ester shifted the intracellular pH dependence of Na-H exchange by 0.10-0.15 pH units in the alkaline direction in adult rat heart myocytes.
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