Population
Rat papillary muscle
Comparison
Phenylephrine with or without protein kinase C… vs Phenylephrine alone or control conditions
Design
Preclinical
Authors
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Does not implicate PKC in alpha1-mediated inotropy; hypothesis-generating for alternative mechanisms in cardiac muscle.
This preclinical study demonstrates that protein kinase C activation is not involved in the alpha 1-adrenoceptor-mediated positive inotropic and electrophysiological effects in rat papillary muscle.
Endou et al. (1991) studied this question.
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