January 1, 1988The Journal of Kansai Medical UniversityOpen Access

Pharmacological Study on the Role of Phosphoinositide Breakdown in Inotropic Response Mediated by Phenylephrine-induced Stimulation of ^|ᵃlpha;1-Adrenoceptors in the Rat Left Ventricular Papillary Muscle

View Full Paper

Ask AI

Bookmark

Population

Rat left ventricular papillary muscle

Design

Preclinical

Authors

HOHitomi OtaniTokyo City University

Discussion

Member takes

Implication

Does not support alpha1-agonist use in patients; leaves open IP3/DAG roles in human cardiac inotropy.

Structured PICO

Population

Rat left ventricular papillary muscle

Intervention

Alpha 1-adrenoceptor stimulation with phenylephrine in the presence of propranolol, with or without various modulators (prazosin, neomycin, 2,3-diphosphoglyceric acid, nifedipine, Mn2+, phorbol-12,13-dibutyrate)

Outcome

Inotropic response and phosphoinositide breakdown (PI-4,5-P2 hydrolysis and IP3 formation)surrogate

Cardiac alpha 1-adrenoceptor stimulation mediates inotropic effects through the cleavage of PI-4,5-P2, utilizing IP3 for transient calcium mobilization and diacylglycerol for sustained calcium channel potentiation.

Cite This Study

Hitomi Otani (1988) studied this question.

synapsesocial.com/papers/6a1709b2b082e78ad77bcd6a https://doi.org/10.5361/jkmu1956.40.1_44

View Full Paper

Ask AI

Bookmark

Pharmacological Study on the Role of Phosphoinositide Breakdown in Inotropic Response Mediated by Phenylephrine-induced Stimulation of ^|ᵃlpha;1-Adrenoceptors in the Rat Left Ventricular Papillary Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pharmacological Study on the Role of Phosphoinositide Breakdown in Inotropic Response Mediated by Phenylephrine-induced Stimulation of ^|ᵃlpha;1-Adrenoceptors in the Rat Left Ventricular Papillary Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider