Key result
The alpha-1 agonist phenylephrine significantly prolonged the duration of outward tail currents in rat dorsal raphe neurons from 0.32 seconds to 1.3 seconds (p<0.001).
Effect estimate: 306% of control
Absolute Event Rate: 1.3% vs 0.32%
p-value: p=<0.001
Phosphoinositide turnover likely mediates modulatory or negative-feedback effects of alpha 1-adrenoceptors rather than their major excitatory effects in rat dorsal raphe neurons.
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Findings in rat neurons warrant no change in alpha-1 agonist use; leaves open phosphoinositide mediation of adrenoceptor effects in vivo.
Freedman et al. (1987) studied Healthy (preclinical animal model). Phenylephrine vs. Baseline (pre-drug application) was evaluated on Duration of outward tail current (seconds) (306% of control, p=<0.001). The alpha-1 agonist phenylephrine significantly prolonged the duration of outward tail currents in rat dorsal raphe neurons from 0.32 seconds to 1.3 seconds (p<0.001).
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