Evidence from localization studies, mouse models, and biochemical characterization suggests that in vivo mixing of actin isoforms may influence cytoskeletal function in cells.
This review highlights that despite high sequence similarity, the six mammalian actin isoforms perform distinct cellular functions.
Although actin is often thought of as a single protein, in mammals it actually consists of six different isoforms encoded by separate genes. Each isoform is remarkably similar to every other isoform, with only slight variations in amino acid sequence. Nevertheless, recent work indicates that actin isoforms carry out unique cellular functions. Here, we review evidence drawn from localization studies, mouse models, and biochemical characterization to suggest a model for how in vivo mixing of actin isoforms may influence cytoskeletal function in cells.
Perrin et al. (Sun,) reported a review. Evidence from localization studies, mouse models, and biochemical characterization suggests that in vivo mixing of actin isoforms may influence cytoskeletal function in cells.