Key result
Evidence from localization studies, mouse models, and biochemical characterization suggests that in vivo mixing of actin isoforms may influence cytoskeletal function in cells.
This review highlights that despite high sequence similarity, the six mammalian actin isoforms perform distinct cellular functions.
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May influence cytoskeletal dynamics in cardiac cells; hypothesis-generating and leaves open therapeutic relevance.
Perrin et al. (2010) reported a review. Evidence from localization studies, mouse models, and biochemical characterization suggests that in vivo mixing of actin isoforms may influence cytoskeletal function in cells.
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