October 1, 1983Molecular and Cellular Biology
Human Actin Genes Are Single Copy for α-Skeletal and α-Cardiac Actin but Multicopy for β- and γ-Cytoskeletal Genes: 3′ Untranslated Regions Are Isotype Specific but Are Conserved in Evolution
Key result
Human alpha-skeletal and alpha-cardiac muscle actin genes exist as single copies in the genome, whereas beta and gamma cytoskeletal actin genes are present in multiple copies.
Population
Human genome / actin genes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical implications for actinopathies; leaves open functional roles of cytoskeletal actin copy number in human disease.
Structured PICO
P
Population
Human genome / actin genes
I
Intervention
Isotype-specific subclones from the 3' untranslated regions of actin cDNAs used as hybridization probes
O
Outcome
Number and organization of actin isotypes in the human genome
Demonstrates that human alpha-skeletal and alpha-cardiac muscle actin genes are single copy, while cytoskeletal actins are multicopy, providing insights into the evolution of multigene families.
Cite This Study
Ponte et al. (1983) studied this question. Human alpha-skeletal and alpha-cardiac muscle actin genes exist as single copies in the genome, whereas beta and gamma cytoskeletal actin genes are present in multiple copies.