Key result
Conserved CArG box motifs in the human skeletal alpha-actin gene direct tissue-specific expression.
Population
Human skeletal alpha-actin gene and its 5' regulatory region, transfected into heterologous rat L8 myogenic…
Design
Preclinical
Authors
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May guide research on muscle gene regulation; leaves open any clinical relevance to human myopathies or cardiomyopathies.
The study identifies key conserved regulatory domains, such as the CArG box, responsible for the tissue-specific expression of the human skeletal alpha-actin gene.
Taylor et al. (1988) studied this question. Cloning and sequencing of human skeletal alpha-actin gene was evaluated on Gene sequence and expression regulation. The human skeletal alpha-actin gene contains conserved regulatory sequences, notably the CArG box motifs, which direct tissue-specific and differentiation-regulated expression.
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