Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.
Key result
Alpha-skeletal and alpha-cardiac muscle actin genes are single copy in the human genome, whereas the cytoskeletal actins, beta and gamma, are present in multiple copies.
Population
Human genome / human genomic actin clones
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Single-copy muscle actins may enable tight cardiac isoform control; leaves open roles in human cardiomyopathy.
Structured PICO
P
Population
Human genome / human genomic actin clones
I
Intervention
Isotype-specific subclones from 3' untranslated regions used as hybridization probes
O
Outcome
Number and organization of actin isotypes in the human genomesurrogate
Demonstrates that alpha-skeletal and alpha-cardiac muscle actin genes are single copy in the human genome, unlike the multicopy cytoskeletal actins.
Cite This Study
Ponte et al. (1983) studied this question. Alpha-skeletal and alpha-cardiac muscle actin genes are single copy in the human genome, whereas the cytoskeletal actins, beta and gamma, are present in multiple copies.