Pumpkin (Cucurbita maxima) seed extract ameliorates letrozole and high-fat diet-induced PCOS in rats via SIRT1/AMPK/NF-κB signaling

SUHASINI SIDRAMAESHWAR; Martin Asha

doi:10.1039/d6fo00600k

January 1, 2026Food & Function

Pumpkin (Cucurbita maxima) seed extract ameliorates letrozole and high-fat diet-induced PCOS in rats via SIRT1/AMPK/NF-κB signaling

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to investigate the effects of pumpkin seed extract on PCOS induced by letrozole and high-fat diet in rats.
Rats were treated with letrozole and a high-fat diet to induce PCOS.
Pumpkin seed extract was administered to assess its effect on the SIRT1/AMPK/NF-κB signaling pathway.
Biochemical and hormonal assessments were conducted to evaluate outcomes.
Pumpkin seed extract significantly decreased levels of androgen hormones, with p<0.05 reported.
Increased SIRT1 and AMPK activation was observed, correlating with reduced NF-κB activity.
Marked improvement in ovarian morphology was noted, indicative of reduced PCOS symptoms.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Examines the effects of pumpkin seed extract on PCOS caused by letrozole and a high-fat diet, suggesting potential benefits in treatment.

Abstract

Polycystic ovarian syndrome (PCOS) is a multifactorial metabolic endocrine disorder that affects reproductive-aged women. While previous studies have established the role of pumpkin seed in the management of metabolic disorders...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

SIDRAMAESHWAR et al. (2026) studied this question.

synapsesocial.com/papers/6a338de8630953a74978eac2 https://doi.org/10.1039/d6fo00600k

View Full Paper

Ask AI

Bookmark

Share

Pumpkin (Cucurbita maxima) seed extract ameliorates letrozole and high-fat diet-induced PCOS in rats via SIRT1/AMPK/NF-κB signaling

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Pumpkin (Cucurbita maxima) seed extract ameliorates letrozole and high-fat diet-induced PCOS in rats via SIRT1/AMPK/NF-κB signaling

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading