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June 18, 2026Nucleic Acids ResearchOpen Access

Structures of DnaA domain I reveal a dimer conserved across Actinomycetes

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Authors

PEPorter K. EllisBSBindu Y. SrinivasuJOJose Chavez Orozco

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Overview

Research reveals conserved DnaA dimer formation in Actinomycetes, indicating its role in replication initiation.

Key Points

  • To explore the structure and function of DnaA domain I in DNA replication initiation across Actinomycetes.
  • Analyzed DnaA domain I structures from 10 Actinomycete species.
  • Conducted biochemical oligomerization assays.
  • Utilized hydrogen-deuterium exchange mass spectrometry (HDX-MS) to study dimerization.
  • Identified a unique dimer structure in DnaA domain I across all examined Actinomycetes species.
  • Demonstrated dimer formation with micromolar affinities.
  • Highlighted the conservation of key elements supporting DnaA self-interaction throughout the group.

Cite This Study

Ellis et al. (2026) studied this question.

synapsesocial.com/papers/6a338e3f630953a74978ef2dhttps://doi.org/10.1093/nar/gkag596
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