Why the study?
Clot-in-transit is associated with severe pulmonary embolism and higher mortality, but its optimal treatment is not established.
Case Report (n=2)
Clot-in-transit is a highly unstable and potentially rapidly fatal condition that requires emergent multidisciplinary evaluation and prompt management decisions.
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Mobile right-heart clot-in-transit may cause fatal arrest within minutes; leaves optimal management open to prospective study.
Clot-in-transit is associated with severe pulmonary embolism and higher mortality than acute pulmonary embolism without clot-in-transit. The optimal treatment of clot-in-transit is not established. Multiple treatment options have been described, including anticoagulation alone, systemic thrombolysis, surgical embolectomy and endovascular catheter-based therapies. Clot-in-transit can embolize to the pulmonary circulation in a matter of seconds and be immediately fatal. We describe two cases of clot-in-transit which embolized quickly upon Intensivist's evaluation and were associated with serious consequences. Management decisions for clot-in-transit should be emergent and based on multidisciplinary discussion of the pulmonary embolism response team.
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Igwilo et al. (2023) conducted a case report in Clot-in-transit with acute pulmonary embolism (n=2). Clot-in-transit was evaluated on Clinical outcome following clot embolization.
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