Key result
Surgical VSD closure restores biventricular function and NYHA class I in two TAB2 cardiomyopathy cases.
Why the study?
TAB2 gene abnormalities cause congenital heart disease and cardiomyopathy, but reports describing cardiac surgery complicated by cardiomyopathy and TAB2 gene anomalies are scarce.
Case Report (n=2)
No
Surgical closure of ventricular septal defects can be successfully performed in children with TAB2 gene anomalies and associated cardiomyopathy.
May support VSD closure feasibility in TAB2 cardiomyopathy; leaves open need for larger studies before practice change.
INTRODUCTION: TAB2 gene abnormalities are known to cause congenital heart disease, cardiomyopathy, and extracardiac malformations. However, there is a paucity of reports describing cardiac surgery complicated by cardiomyopathy and TAB2 gene anomalies. We present 2 cases of successful closure of ventricular septal defects (VSDs) with a dilated left ventricle and impaired cardiac function accompanied by TAB2 gene anomalies.
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Ugaki et al. (2026) conducted a case report in Ventricular Septal Defect with TAB2 gene anomalies and cardiomyopathy (n=2). Surgical patch closure of ventricular septal defect was evaluated on Clinical recovery and ventricular function improvement. Surgical patch closure of ventricular septal defects successfully improved biventricular function and achieved NYHA class I status in two children with TAB2 gene abnormalities and cardiomyopathy.
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