Key result
Transcatheter VSD closure achieves 100% procedural success with stable hemodynamics and symptom improvement.
Why the study?
Untreated ventricular septal defects in children can progress to severe symptoms such as pulmonary hypertension and heart failure, motivating evaluation of minimally invasive transcatheter closure using VSD occluder devices to restore normal blood flow dynamics and manage symptoms.
Does transcatheter closure using a VSD occluder device improve symptoms and hemodynamics in pediatric patients with severely symptomatic untreated VSDs?
Case Report (n=4)
Does transcatheter closure using a VSD occluder device improve symptoms and hemodynamics in pediatric patients with severely symptomatic untreated VSDs?
Answers are grounded in this paper and cite their sources.
This case series demonstrates the feasibility, safety, and symptomatic benefit of transcatheter VSD occlusion in pediatric patients presenting with late, severe complications of untreated VSDs.
Ventricular septal defects (VSDs) are among the most common congenital heart defects in children, caused by incomplete formation of the interventricular septum during fetal development. The prevalence of VSDs is estimated at approximately 5.6 per 1,000 live births when identified through advanced imaging techniques. This study involved four pediatric patients aged 8 to 12 years who presented with severe symptoms of untreated VSDs, including exercise intolerance, cyanosis, pulmonary hypertension, recurrent respiratory infections, and heart failure. Given the progression of their conditions, a multidisciplinary team recommended transcatheter closure using a VSD occluder device as a minimally invasive approach to seal the defect and restore normal blood flow dynamics. Comprehensive pre-procedural assessments were conducted for each patient, including electrocardiography (ECG), transthoracic echocardiography (TTE), and blood tests to evaluate cardiovascular health. The implantation procedures were performed under general anesthesia, successfully deploying devices without intraoperative complications. Post-operative evaluations indicated stable hemodynamics and significant symptom improvement in all cases. This study underscores the safety and effectiveness of transcatheter closure techniques for managing VSDs in pediatric patients, highlighting the critical importance of timely intervention to prevent severe complications. Future research involving larger patient populations is recommended to validate these findings further and optimize treatment strategies for congenital heart defects.
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Pramodkumar et al. (2026) conducted a case report in Untreated ventricular septal defects (VSDs) with severe symptoms (n=4). Transcatheter closure using a ventricular septal defect (VSD) occluder device was evaluated on Procedural success, hemodynamics, and symptom improvement.
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