Key result
Nicotinic or electrical stimulation of intrinsic cardiac ganglia in rabbit hearts produced bradycardia, tachycardia, or biphasic responses, with significant AV conduction prolongation at specific sites.
Why the study?
Does nicotinic or electrical stimulation of intrinsic cardiac ganglia alter sinus rate and atrioventricular conduction in the rabbit heart?
Does nicotinic or electrical stimulation of intrinsic cardiac ganglia alter sinus rate and atrioventricular conduction in the rabbit heart?
Stimulation of intrinsic cardiac ganglia produces independent selective effects on cardiac electrophysiology, highlighting a potential therapeutic target for cardiac disease.
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Rabbit ganglion stimulation shows site-specific rate and conduction effects; leaves open translation to human autonomic therapies.
Allen et al. (2018) studied this question. Nicotinic or electrical stimulation of intrinsic cardiac nerve plexus was evaluated on Functional effects on sinus rate and atrioventricular conduction. Nicotinic or electrical stimulation of intrinsic cardiac ganglia in rabbit hearts produced bradycardia, tachycardia, or biphasic responses, with significant AV conduction prolongation at specific sites.
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