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Contrast-enhanced ultrasonography improves detection of the perfusion and vascularity of organs. Its main indication is the assessment of focal lesions in the liver and spleen, particularly with regard to differentiating between benign and malignant processes. Evidence suggests that contrast-enhanced ultrasonography may be a valuable alternative to invasive diagnostic procedures such as fine-needle aspiration and core biopsy.
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Haers et al. (2009) studied this question.
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