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June 19, 2026Diabetes & MetabolismOpen Access

CGM-based metrics and mortality in older adults living with type 2 diabetes on insulin therapy: a secondary analysis of the HYPOAGE study

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Authors

SSSarra SmatiABAnne‐Sophie BoureauPGPierre Gourdy

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Overview

Randomized trial investigates glycated variability's impact on mortality risk in older adults with type 2 diabetes, suggesting clinical implications.

Key Points

  • The aim is to identify CGM-derived metrics associated with all-cause mortality in older adults with type 2 diabetes on insulin therapy.
  • Secondary analysis of the HYPOAGE study, a multicenter prospective study
  • Included 141 insulin-treated older adults aged 75+ with continuous glucose monitoring for 28 days
  • Used multivariable Cox regression to explore risk factors for mortality, controlling for various health metrics.
  • After 44 months of follow-up, 58 of 141 participants died.
  • Higher levels of time below range and glycemic variability were linked to increased mortality (hazard ratios 1.51, 1.76 respectively).
  • Glycemic variability levels ≤ 36% were tied to a lower risk of mortality (hazard ratio 0.57).

Cite This Study

Smati et al. (2026) studied this question.

synapsesocial.com/papers/6a34dc9f65a5b0777af2cc8ahttps://doi.org/10.1016/j.diabet.2026.101775
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