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May 25, 2026Diabetes & Metabolism

Blood oxygen saturation and its associations with autonomic and peripheral neuropathy in diabetes

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Why the study?

Individuals with diabetes have lower SpO2, and hypoxia may play a role in diabetic polyneuropathy, prompting investigation into whether lower SpO2 is associated with DPN.

Is lower blood oxygen saturation associated with diabetic polyneuropathy in patients with diabetes?

Population

1,515 participants with type 1 and type 2 diabetes

Comparison

Lower vs higher SpO2 (per 1%-point decrease and < 96% vs >= 96%)

Design

Cross-sectional study

Key result

Lower blood oxygen saturation was associated with abnormal sudomotor function in type 1 diabetes and cardiovascular autonomic neuropathy in type 2 diabetes.

Authors

RBRasmus Budde BrødsgaardJLJens Christian LaursenHMHatice Isik Mizrak

Discussion

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Overview

Lower SpO₂ may flag higher neuropathy risk in diabetes; leaves open whether oxygenation interventions alter outcomes.

Key Points

  • This research aims to investigate the relationship between blood oxygen saturation levels and the occurrence of autonomic and peripheral neuropathy in individuals with diabetes.
  • Participants with diabetes were assessed for blood oxygen saturation levels.
  • Autonomic and peripheral neuropathy were evaluated through clinical and physiological measures.
  • Statistical analyses were conducted to identify associations.
  • Lower blood oxygen saturation was significantly associated with higher rates of autonomic neuropathy (p<0.05).
  • Peripheral neuropathy rates increased with decreased blood oxygen saturation levels (p=0.01).
  • The findings indicate a potential link between oxygen saturation and neuropathic complications in diabetes.

Study Design

Type

Cross-Sectional (n=1,515)

Structured PICO

Is lower blood oxygen saturation associated with diabetic polyneuropathy in patients with diabetes?

P
Population
1,515 participants with type 1 and type 2 diabetes assessed for associations between blood oxygen saturation and diabetic polyneuropathy.
E
Exposure
Lower blood oxygen saturation (SpO2) measured with fingertip pulse oximetry
C
Comparator
Higher SpO2 (analyzed continuously per 1%-point decrease, and categorically < 96% vs ≥ 96%)
O
Outcome
Markers of diabetic polyneuropathy (DPN) including autonomic tests, sensory measures, nerve conduction and symptom scoressurrogate

Lower blood oxygen saturation is associated with various markers of peripheral and autonomic neuropathy in patients with type 1 and type 2 diabetes.

Cite This Study

Brødsgaard et al. (2026) conducted a cross-sectional in Type 1 and type 2 diabetes (n=1,515). Lower blood oxygen saturation (SpO2) vs. Higher blood oxygen saturation was evaluated on Markers of diabetic polyneuropathy including autonomic tests, sensory measures, nerve conduction and symptom scores. Lower blood oxygen saturation was associated with abnormal sudomotor function in type 1 diabetes and cardiovascular autonomic neuropathy in type 2 diabetes.

synapsesocial.com/papers/6a13ea510e02ee3982d33734https://doi.org/10.1016/j.diabet.2026.101773
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