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This study aims to evaluate the immunomodulatory effects of interleukin-10 genetically modified mesenchymal stem cells in vitro and in vivo.

Interleukin-10-engineered mesenchymal stem/stromal cells exhibit robust immunomodulatory effects in vitro and in vivo

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This study aims to evaluate the immunomodulatory effects of interleukin-10 genetically modified mesenchymal stem cells in vitro and in vivo.
Genetically engineered bone marrow-derived MSCs to express mouse IL-10 through lentiviral transduction.
In vitro assessments included co-cultures with LPS and IFN-γ stimulated macrophages and Con A-stimulated splenocytes.
In vivo evaluation involved treating BALB/c mice with endotoxemia and assessing survival, cytokines, and inflammation.
MSC-IL-10 significantly decreased pro-inflammatory cytokine production in vitro compared to MSC-WT.
In vivo, MSC-IL-10 reduced systemic inflammatory cytokines and improved leukocyte profiles and tissue damage.
Biodistribution showed MSC-IL-10 targeting organs like the liver, lungs, and spleen after endotoxemia.

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Randomized trial demonstrates enhanced immunomodulatory effects in inflammatory conditions using MSCs, suggesting potential therapeutic benefits.

Carneiro et al. (2026) studied this question.

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Randomized trial demonstrates enhanced immunomodulatory effects in inflammatory conditions using MSCs, suggesting potential therapeutic benefits.