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June 19, 2026Open Research EuropeOpen Access

Maternal prenatal stress and its neuropsychological sequelae in infants and mother–infant dyadic quality: A systematic review and meta-analysis protocol

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Authors

VVVanesa María Salmerón VegaUniversidad de GranadaLLLaura Leonardo-EncaboUniversidad Loyola AndalucíaATAlejandro de la Torre-LuqueUniversidad Complutense de Madrid

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Implication

Systematic review protocol investigates neuropsychological effects of maternal stress on infants, highlighting important health implications.

Key Points

  • This research aims to examine how maternal prenatal stress impacts neurodevelopmental outcomes in infants and the quality of mother-infant interactions.
  • Systematic review and meta-analysis according to PRISMA-P guidelines.
  • Inclusion of cohort and case-control studies with validated chronic prenatal stress assessments in pregnant women.
  • Analysis using random-effects models in R, assessing risk of bias and evidence certainty.
  • Anticipated findings will demonstrate significant correlations between chronic maternal prenatal stress and infant neurodevelopmental outcomes.
  • Statistical evaluations will reveal levels of HPA axis dysregulation as measured by glucocorticoid levels.
  • Identification of trends in mother-infant dyadic quality related to maternal stress levels.

Cite This Study

Vega et al. (2026) studied this question.

synapsesocial.com/papers/6a34de4165a5b0777af2db08https://doi.org/10.12688/openreseurope.23717.1
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