Concurrent Manifestation of Crescentic Anti-glomerular Basement Membrane Nephritis and Membranous Nephropathy

A BSTRACT Co-existence of anti-glomerular basement membrane (GBM) nephritis and membranous nephropathy (MN) is exceedingly rare. MN can occur simultaneously or sequentially to anti-GBM nephritis. Here, we report a patient with gout having severe renal dysfunction. Light microscopy revealed crescentic glomerulonephritis. Linear and granular positivity in the capillary wall was noted for immunoglobulin G. Serum and immunohistochemistry for PLA2R were negative. He developed end-stage renal disease and is hemodialysis dependent. Careful evaluation of immunofluorescence helps in clinching the diagnosis. The factors which predict renal outcome include serum creatinine at presentation; hence, earlier detection may lead to the reversal of renal function.