Fabrication and evaluation of antibacterial properties of a novel surgical suture coated with green synthesized chitosan nanoparticles using Mimosa pudica extract – An in vitro study

Objectives: This study aimed to fabricate and evaluate the antibacterial properties of Vicryl surgical sutures coated with green-synthesized chitosan nanoparticles using Mimosa pudica extract. Methods: Methanolic extract of Mimosa pudica leaves was prepared and used for phytosynthesis of chitosan nanoparticles. Chitosan was mixed with acetic acid, centrifuged, and processed to obtain nanoparticles. The synthesized nanoparticles were coated onto Vicryl sutures using an immobilization technique via slurry dipping. Antibacterial efficacy of the coated sutures was evaluated using the disk diffusion method and compared with uncoated sutures. Results: Chitosan nanoparticles were successfully synthesized and effectively coated onto surgical sutures. The nanoparticle-coated sutures demonstrated significant antibacterial activity compared to uncoated sutures, indicating enhanced inhibition of microbial growth. Conclusions: Green-synthesized chitosan nanoparticle-coated sutures show promising antibacterial properties and may serve as an effective strategy to reduce postoperative wound infections. Their biocompatibility, biodegradability, and eco-friendly synthesis make them a potential alternative in surgical applications, although further in vivo studies are needed to confirm clinical efficacy.