Secondary Intention Healing and Re‐Volumization After Mohs Surgery With a Collagen‐Mānuka Honey‐Hydroxyapatite Dressing: A Prospective Study

Background Secondary intention healing (SIH) after Mohs micrographic surgery (MMS) is often limited by delayed closure, infection risk, and infrequent follow‐up. Traditional surface‐area assessments overlook wound depth. Re‐volumization, wound depth restoration, may better indicate healing progress. A novel, patient‐administered collagen–Mānuka honey–hydroxyapatite dressing (CHD) has demonstrated benefits in reducing pain and progressing healing. Objective Evaluate efficacy, safety, and satisfaction of CHD in at‐home SIH after MMS, emphasizing re‐volumization. Methods and Materials In this IRB‐approved prospective study, 10 adults with full‐thickness post‐MMS wounds applied CHD daily for 2 months via a durable medical equipment (DME) model. Wounds assessed by area, volume, photography, scar scales, and satisfaction. Safety monitored via adverse events. Results Baseline wound area and volume averaged 2.99 cm² and 2.35 cm³. Wound area decreased linearly; volume decreased exponentially, with 50% achieving full re‐volumization within 1 month and 90% achieving > 90% by 2 months. Investigators rated healing speed 8.0/10; patients rated 8.67/10. Pain was minimal, scar appearance favorable, and satisfaction high (8.25/10). Dressing was simple to use, empowering independent at‐home healing. One withdrew due to secondary adhesive irritation; no serious adverse events. Conclusion CHD is a suitable, affordable, patient‐administered option for SIH after MMS, demonstrating rapid re‐volumization, minimal pain, and high satisfaction.