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This research examines the neuroprotective effects of vitamins B5 and B12 in a mouse model of Parkinson's disease.

June 19, 2026Food FrontiersOpen Access

Neuroprotective Effects of Biosynthetic d ‐Calcium Pantothenate and Cyanocobalamin Against MPTP‐Induced Parkinsonism via Microbiota Modulation, Metabolic Homeostasis Restoration, and Endoplasmic Reticulum Stress Inhibition

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Randomized trial investigates the effects of vitamins B5 and B12 on Parkinson's disease models, suggesting a potential nutritional intervention.

This research examines the neuroprotective effects of vitamins B5 and B12 in a mouse model of Parkinson's disease.
Performed biochemical, untargeted metabolomic, 16S microbiota, and Western blot analyses in MPTP-induced PD mice.
Supplementation involved administering vitamin B5 and B12 to assess their effects on various physiological parameters.
Mice receiving vitamins exhibited improved motor function and reduced oxidative stress.
Endoplasmic reticulum stress was inhibited by downregulating the PERK-eIF2α-ATF4-CHOP pathway.
Interventions led to modulation of gut microbiota, decreasing Desulfovibrio and increasing Prevotella abundance.

Chen et al. (2026) studied this question.

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Randomized trial investigates the effects of vitamins B5 and B12 on Parkinson's disease models, suggesting a potential nutritional intervention.